The City Science Network is an international community of institutions and researchers that share the common goal of enabling more livable, equitable, and resilient communities. The network, started ten years ago, now includes ten international nodes including: Biobío, Chile; Guadalajara, Mexico; Toronto, Canada; Andorra; Gipuzkoa, Spain; Hamburg, Germany; Taipei, Taiwan; Shanghai, China; and Israel in addition to our lab at MIT in Cambridge. As a network we propose that transnational problems such as climate change and public health are best addressed in cities, one community at a time. Future cities, described as clusters of high-performing, entrepreneurial, and walkable communities, would allow for neighborhoods that aspire to achieve the following goals: zero commuting, zero energy, maximum creative collisions, maximum equity, and maximum public health. These communities will offer a unique combination of density, diversity, access, and public amenities to inspire, promote social interaction, ensure equity, and increase creative and entrepreneurial engagement1.